(Figure 2).

(Figure 2).

The rise of Large Language Models (LLMs) has enabled the development of specialized AI agents with domain-specific reasoning and interaction capabilities, particularly in healthcare. While recent frameworks simulate medical decision-making, they largely focus on single-turn tasks where a doctor agent receives full case information upfront -- diverging from the real-world diagnostic process, which is inherently uncertain, interactive, and iterative. In this paper, we introduce MIMIC-Patient, a structured dataset built from the MIMIC-III electronic health records (EHRs), designed to support dynamic, patient-level simulations. Building on this, we propose DynamiCare, a novel dynamic multi-agent framework that models clinical diagnosis as a multi-round, interactive loop, where a team of specialist agents iteratively queries the patient system, integrates new information, and dynamically adapts its composition and strategy. We demonstrate the feasibility and effectiveness of DynamiCare through extensive experiments, establishing the first benchmark for dynamic clinical decision-making with LLM-powered agents.

In high-stakes domains like clinical reasoning, AI assistants powered by large language models (LLMs) are yet to be reliable and safe. We identify a key obstacle towards reliability: existing LLMs are trained to answer any question, even with incomplete context in the prompt or insufficient parametric knowledge. We propose to change this paradigm to develop more careful LLMs that ask follow-up questions to gather necessary and sufficient information and respond reliably. We introduce MEDIQ, a framework to simulate realistic clinical interactions, which incorporates a Patient System and an adaptive Expert System. The Patient may provide incomplete information in the beginning; the Expert refrains from making diagnostic decisions when unconfident, and instead elicits missing details from the Patient via follow-up questions. To evaluate MEDIQ, we convert MEDQA and CRAFT-MD -- medical benchmarks for diagnostic question answering -- into an interactive setup. We develop a reliable Patient system and prototype several Expert systems, first showing that directly prompting state-of-the-art LLMs to ask questions degrades the quality of clinical reasoning, indicating that adapting LLMs to interactive information-seeking settings is nontrivial. We then augment the Expert with a novel abstention module to better estimate model confidence and decide whether to ask more questions, thereby improving diagnostic accuracy by 20.3%; however, performance still lags compared to an (unrealistic in practice) upper bound when full information is given upfront. Further analyses reveal that interactive performance can be improved by filtering irrelevant contexts and reformatting conversations. Overall, our paper introduces a novel problem towards LLM reliability, a novel MEDIQ framework, and highlights important future directions to extend the information-seeking abilities of LLM assistants in critical domains.